American International Journal of Multidisciplinary Scientific Research en-US (Managing Editor) (Administrator) Sun, 14 Oct 2018 00:00:00 +0000 OJS 60 Assessment of Passengers’ Satisfaction of Public Transport System in Akure-Owo Axis, Nigeria <p style="text-align: justify;">This study assesses passengers’ satisfaction of public transport system in Akure-Owo axis, Nigeria. It was necessitated by the poor nature of transport system which has created impediments to the smooth movement of people, goods and services in some of urban centres in Nigeria. Meanwhile, the importance of public transport in cities of many developing countries lies in the fundamental fact that accessibility and mobility are essential for economic growth and also for effective and efficient movement of goods and services. Twelve bus services were identified. The study was conducted using questionnaires and field observation to collect the required data at the terminals (i.e. Akure and Owo Park). One hundred and twelve (112) questionnaires were administered to the passengers across the two terminals. Descriptive tool such as weighted mean and standard deviation were employed. Also, Gap analysis was used to achieve descriptive statistics. Findings revealed that passengers were not satisfied with the competence of drivers, condition of vehicle, overloading and over-speeding, attitude of drivers, driver’s compliance with road safety rules and order, and the cost charge per trip. Based on the dissatisfactions, recommendations were suggested.</p> Olorunfemi, Samuel Oluwaseyi, Adeniran, Adetayo Olaniyi ##submission.copyrightStatement## Sun, 14 Oct 2018 00:00:00 +0000 Higher Serum Levels of Stromelisyn 2 (MMP10) but not Matrilysin (MMP7) in Patients with End-Stage Chronic Kidney Disease on Chroniodialysis <p style="text-align: justify;">Matrix metalloproteinases (MMPs) are endopeptidases with proteolytic activity against components of extracellular matrix, such as collagen and elastin, which are involved in many biological and pathophysiological processes in humans. There is some evidence for MMPs` role in nephrogenesis, renal damage, and remodeling, such as MMP-7 (matrilysin) and MMP-10 (stromelysin). However, the implication of MMPs in the pathogenetic renal changes in patients with chronic kidney disease (CKD) is poorly understood. Therefore, we aimed to measure the serum levels of circulating MMP-7 and MMP-10 in patients at different stages of chronic kidney disease and to analyze the impact of MMP-7 and MMP-10 on the renal disease burden of these patients. In our study, we have evaluated 80 persons – 20 with CKD (II – IV stage), 20 with end-stage CKD on chronic hemodialysis, and 40 age and sex-matched control subjects: 20 with isolated arterial hypertension and 20 healthy persons. The serum samples were tested for MMP-7 and MMP-10 by performing enzyme immunoassay method. Serum levels of both investigated MMPs were most increased in end-stage CKD patients on hemodialysis. The concentration of MMP10 was significantly higher in CKD patients on chroniodialysis than healthy persons (p &lt; 0.001), and patients with isolated arterial hypertension (p &lt; 0.001) and patients at different stages of CKD (p = 0.037). To conclude, it is possible that the increased levels of MMP-10 could be associated with poor prognosis and eventually need for dialysis treatment at earlier stages. We hypothesize that CKD is associated with alterations of MMPs and that may be related to the severity of atherosclerosis in this clinical setting.</p> Tsvetelina Velikova, Toni Velikov, Georgi Mihailov ##submission.copyrightStatement## Fri, 09 Nov 2018 09:08:36 +0000